Wellness

Glutathione injections: what the body uses it for, and what to expect

Glutathione is one of the most promised-about substances in wellness. Here is what it is, what it does, and where the evidence stops.

Published 6 October 20263 min readPolished Beauty London

Every cell in your body makes glutathione. It is a small molecule built from three amino acids, and its job is to neutralise the reactive by-products of simply being alive: the oxidative stress from exercise, pollution, alcohol, illness and sunlight. Levels fall with age and with hard living.

What an injection does

It delivers glutathione straight into circulation, bypassing a gut that absorbs it poorly. People who have it regularly often describe clearer skin, better recovery after exercise or a heavy week, and feeling generally less run down. Those are the effects with the best support.

What it does not do

Photography to come.

How the appointment goes

A short conversation, the medical form on a first visit, and a small cannula placed in a vein in the arm. The glutathione is given slowly over a few minutes, sometimes with vitamin C in the same sitting, and the cannula comes out. Fifteen minutes, a plaster, and back to the day. Some people notice a faint warmth or a metallic taste for a moment; neither lasts.

A realistic course

What the evidence supports, and what it does not

The evidence for glutathione as an antioxidant that supports recovery is reasonable. The evidence for it as a treatment that changes the appearance of skin on its own is thinner, and the clinic says so. The claims that travel with it online, about lightening skin or undoing years, are not made here, and a course is never sold on the strength of them. If you want brighter, clearer skin, the facials and the boosters do that job with far better evidence behind them, and glutathione is a support rather than a substitute.

Questions people ask

Is it safe: at the doses used here, for people without asthma or a relevant condition, yes, and the medical form is where those are checked. Will I feel it: some people feel a warmth or a taste for a moment; most feel nothing on the day and a general lift over a week or two. How often: weekly for a month then monthly is common; a single injection around a treatment is the other pattern. Does it lighten skin: no, and the clinic does not use it for that purpose or at doses that could.

For brighter, clearer skin, the facials and the boosters remain the treatments with the evidence behind them, and glutathione sits alongside them rather than in their place.

For most people, a run of weekly injections for a month, then one a month, is the pattern. The consultation sets it against what you want from it.

Common questions

How is it given?

A slow injection into a vein in the arm, over a few minutes.

Are there side effects?

Very few at the doses used here. Occasionally a mild headache or nausea, briefly. Tell us about asthma, as glutathione can rarely affect breathing in people with it.

Will it make my skin lighter?

No, and that is not what it is for here. Brighter and clearer, sometimes; a change of skin tone, no.

Ask us about this

Anything here you would like explained for your own skin? Ask below. The team reads every question, and replies by email when you leave one.